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Year-round presence of neonicotinoid insecticides in tributaries to the...
To better understand the transport of neonicotinoid insecticides into the Great Lakes, monthly samples (October 2015-September 2016) were collected from 10 tributaries to the... -
Estimating Intermittent Individual Spawning Behavior via Disaggregating Group Data
In order to understand fish biology and reproduction it is important to know the fecundity patterns of individual fish, as frequently established by recording the output of... -
Assessing reproductive effects of aromatase inhibition on fishes with...
Predictive models and frameworks for linking inhibition of the enzyme aromatase, as measured in non-animal high throughput screening assays, to adverse effects on reproduction... -
Effects of early life stage exposure of largemouth bass to atrazine or a...
Largemouth base histological development and transcriptomic changes in gonad tissue after early life stage exposure to Atrazine... -
Derivation and Evaluation of Putative Adverse Outcome Pathways for Effects...
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme activity in... -
Assessment of Endocrine Disruption in the Shenandoah River Watershed –...
This data release presents chemical and biological results from investigations of water quality, fish endocrine disruption, and emergent insects in the Shenandoah River... -
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and...
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase... -
Case study in 21st century ecotoxicology: using in vitro aromatase...
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo)... -
Effects-based monitoring of bioactive contaminants discharged to the...
The present study highlights the utility of bioeffects-based monitoring in conjunction with analytical chemical measurements of surface waters on the Colorado River associated... -
Larval fathead minnow swim bladder inflation following exposure to...
In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in... -
Current use pesticides in larval amphibian tissues, amphibian pathogen and...
The data include concentrations of current use pesticides in tissues of larval wood frog (Lithobates sylvaticus) and spotted salamander (Ambystoma maculatum) and the presence of... -
Maumee River 2012 and 2016
The Maumee River and associated tributaries are an example of a system influenced by a mosaic of contaminant inputs from point and nonpoint sources along a gradient of land... -
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow...
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation for the three... -
Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern. We... -
Quantitative response-response relationships linking aromatase inhibition to...
Data used in the creation of each figure and table cited in Doering et al. (2019; DOI: 10.1021/acs.est.9b02606) are provided. This dataset is associated with the following... -
Occurrence and in vitro bioactivity of estrogen, androgen, and...
In vitro bioactivity concentrations and chemical concentrations of estrogens, androgens, and glucocorticoids from a nationwide screen of United States stream water samples. In... -
Organic contaminants, including hormones, pesticides, pharmaceuticals and...
These data represent surface water and bed sediment samples analyzed for a variety of organic compounds. The samples were collected in streams and rivers in the Chesapeake Bay... -
Secondary screening method for sodium-iodide symporter inhibition utilizing...
Data pertaining to a NIS-expressing cell line, FRTL-5 and it's screening capabilities for confirming inhibitors of NIS-mediated iodide uptake. This dataset is associated with... -
Current use pesticides in larval amphibian tissues, amphibian pathogen and...
The data include concentrations of current use pesticides in tissues of larval wood frog (Lithobates sylvaticus) and spotted salamander (Ambystoma maculatum) and the presence of... -
Assessment of Endocrine Disruption in the Shenandoah River Watershed –...
This data release presents chemical and biological results from investigations of water quality, fish endocrine disruption, and emergent insects in the Shenandoah River...