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Pharmacokinetics of artesunate after single oral administration to rats
Background Artesunate is a commonly used antimalarial drug derived from artemisinin. It is rapidly converted to dihydroartemisinin. Little is known on this conversion in the GI... -
The
The underlying molecular defect resulting in the abnormal calcification observed in ank/ank mice has been identified. The responsible nonsense mutation affects the protein... -
Mutant Rab24 GTPase is targeted to nuclear inclusions
Background Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this... -
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Editorial comment -
The viral transmembrane superfamily: possible divergence of Arenavirus and...
Background Recent studies of viral entry proteins from influenza, measles, human immunodeficiency virus, type 1 (HIV-1), and Ebola virus have shown, first with molecular... -
Paediatric referrals in rural Tanzania: the Kilombero District Study – a case series
Background Referral is a critical part of appropriate primary care and of the Integrated Management of Childhood Illness (IMCI) strategy. We set out to study referrals from the... -
Relationships between volume and pressure measurements and stroke volume...
Objective: To evaluate the relationships between the changes in stroke volume index (SVI), measured in both the aorta and the pulmonary artery, and the changes in intrathoracic... -
The clinical and molecular spectrum of galactosemia in patients from the...
Background The objective of this study was to document the clinical, laboratory and genetic features of galactosemia in patients from the Cape Town metropolitan region. Methods... -
Phylogenetic relationships and taxonomic position of
Background Little is known about phytoplankton communities inhabiting low pH environments such as volcanic and geothermal sites or acidic waters. Only specialised organisms are... -
Development of dengue virus replicons expressing HIV-1 gp120 and other...
Background Toward the goals of providing an additional vector to add to the armamentarium available to HIV vaccinologists and of creating a bivalent vaccine effective against... -
Mesenchymal precursor cells in the blood of normal individuals
Mesenchymal precursor cells found in the blood (BMPCs) of normal persons adhere to plastic and glass and proliferate logarithmically in DMEM-20% fetal calf serum (FCS) without... -
Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic...
Background Lower limb paralysis occurs in 11% of patients after surgical procedure of thoracic or thoracoabdominal aneurysms and is an unpredictable and distressful... -
Structural model of nicotinic acetylcholine receptor isotypes bound to...
Background Nicotine is a psychoactive drug presenting a diverse array of biological activities, some positive, such as enhancement of cognitive performances, others negative,... -
Cytokines as new treatment targets in chronic heart failure
Inflammatory cytokines may negatively influence contractility and contribute to the remodelling process in the failing myocardium. Traditional cardiovascular drugs appear to... -
Prehospital point of care testing of blood gases and electrolytes — an...
Background: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. Results: A portable,... -
In-vivo evaluation of simultaneous administration of incompatible drugs...
Background: Multilumen catheters are commonly used in critically ill children. Their use, however, is associated with significant morbidity. We studied the simultaneous... -
Evrim Bougie: A new instrument in the management of urethral strictures
Background In this study a new instrument and technique is described for the endoscopic treatment of complete posterior urethral strictures, which may result in serious... -
A cohort study of possible risk factors for over-reporting of...
Background The identification of poor medicinal adherence is difficult because direct observation of medication use is usually impractical. Up to 50% of individuals on chronic... -
Biofilm formation by nontypeable
Background Nontypeable Haemophilus influenzae is an important cause of otitis media in children and lower respiratory tract infection in adults with chronic obstructive... -
TNF-α induced endothelial MAdCAM-1 expression is regulated by exogenous, not...
Background MAdCAM-1 is an adhesion molecule expressed in Peyer's patches and lymphoid tissues which is mobilized by cytokines like TNF-α and is a major determinant of lymphocyte...