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Cloning and characterization of the rat homologues of the Inhibitor of Apopto...
Background Inhibitor of Apoptosis (IAP) proteins are key intrinsic regulators of apoptosis induced by a variety of triggers. We isolated the rat Inhibitor of Apoptosis genes 1,... -
Genomic organization and alternative splicing of the human and mouse RPTPρ genes
Background Receptor protein tyrosine phosphatase rho (RPTPρ, gene symbol PTPRT) is a member of the type IIB RPTP family. These transmembrane molecules have been linked to signal... -
Genomic organisation and alternative splicing of mouse and human thioredoxin ...
Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three recognised forms... -
Transcriptional transactivation by selected short random peptides attached to...
Background Transcriptional transactivation is a process with remarkable tolerance for sequence diversity and structural geometry. In studies of the features that constitute... -
Defining signal thresholds in DNA microarrays: exemplary application for inva...
Background Genome-wide or application-targeted microarrays containing a subset of genes of interest have become widely used as a research tool with the prospect of diagnostic... -
Multi site polyadenylation and transcriptional response to stress of a vacuol...
Background Vacuolar type H+-ATPases play a critical role in the maintenance of vacuolar homeostasis in plant cells. V-ATPases are also involved in plants' defense against... -
Manipulation of gene expression by an ecdysone-inducible gene switch in tumor...
Background Rapid, robust and reversible induction of transgene expression would significantly facilitate cancer gene therapy as well as allow the in vivo functional study of... -
Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression i...
Background Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the transcriptionally... -
Extracting biological information from DNA arrays: an unexpected link between...
Background In global gene expression profiling experiments, variation in the expression of genes of interest can often be hidden by general noise. To determine how biologically... -
Delayed union of femoral fractures in older rats:decreased gene expression
Background Fracture healing slows with age. While 6-week-old rats regain normal bone biomechanics at 4 weeks after fracture, one-year-old rats require more than 26 weeks. The... -
A simple method for statistical analysis of intensity differences in microarr...
Background Microarray experiments offer a potent solution to the problem of making and comparing large numbers of gene expression measurements either in different cell types or... -
Empirical characterization of the expression ratio noise structure in high-de...
Background High-density oligonucleotide arrays (HDONAs) are a powerful tool for assessing differential mRNA expression levels. To establish the statistical significance of an... -
Expression profiles during honeybee caste determination
Background Depending on their larval environment, female honeybees develop into either queens or workers. As in other polyphenisms, this developmental switch depends not on... -
Advanced analysis of a
Background Previously, we reported effects of the cryb mutation on circadian rhythms in period and timeless gene expression within isolated peripheral Drosophila tissues. We... -
Poly purine.pyrimidine sequences upstream of the beta-galactosidase gene affe...
Background Poly purine.pyrimidine sequences have the potential to adopt intramolecular triplex structures and are overrepresented upstream of genes in eukaryotes. These... -
Evidence for large domains of similarly expressed genes in the
Background Transcriptional regulation in eukaryotes generally operates at the level of individual genes. Regulation of sets of adjacent genes by mechanisms operating at the... -
Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal ...
Background Members of the ribonuclease III superfamily of double-stranded(ds)-RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in... -
The major transcription initiation site of the
Background The cyclin-dependent kinase inhibitor p27Kip1 is essential for proper control of cell cycle progression. The levels of p27Kip1 are regulated by several mechanisms... -
Evolutionary conservation of
Background Homeobox genes of the orthodenticle (otd)/Otx family have conserved roles in the embryogenesis of head and brain. Gene replacement experiments show that the... -
Heat shock protein gene expression and survival in critical illness
Heat shock protein gene expression and survival in critical illness