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Assessing reproductive effects of aromatase inhibition on fishes with...
Predictive models and frameworks for linking inhibition of the enzyme aromatase, as measured in non-animal high throughput screening assays, to adverse effects on reproduction... -
Derivation and Evaluation of Putative Adverse Outcome Pathways for Effects...
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme activity in... -
SEQUENCING AND DE NOVO DRAFT ASSEMBLIES OF A FATHEAD MINNOW (Pimpehales...
The dataset provides the URLs for accessing the genome sequence data and two draft assemblies as well as fathead minnow genotyping data associated with estimating the... -
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and...
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase... -
Case study in 21st century ecotoxicology: using in vitro aromatase...
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo)... -
Effects-based monitoring of bioactive contaminants discharged to the...
The present study highlights the utility of bioeffects-based monitoring in conjunction with analytical chemical measurements of surface waters on the Colorado River associated... -
Maumee River 2012 and 2016
The Maumee River and associated tributaries are an example of a system influenced by a mosaic of contaminant inputs from point and nonpoint sources along a gradient of land... -
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow...
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation for the three... -
Quantitative response-response relationships linking aromatase inhibition to...
Data used in the creation of each figure and table cited in Doering et al. (2019; DOI: 10.1021/acs.est.9b02606) are provided. This dataset is associated with the following... -
Male Fathead Minnow Transcriptomes and Associated Chemical Analytes in...
This dataset presents the full hepatic transcriptomes of fathead minnows (Pimephales promelas) caged for four days at multiple sites within the Milwaukee Estuary area of concern... -
Contaminants in bald eagles of the upper Midwestern U.S.: A framework for...
Contaminant data from bald eagles in the Upper-Midwest of the US. Dataset contains five tables in total including details of sample collection locations, organic contaminant... -
Adverse Outcome Pathway Networks II: Network Analytics
The data set provides a set of txt files and cytoscape files that were used to construct the example AOP networks included in the paper. Additionally, a supplementary table file... -
The effect of thyroperoxidase and deiodinase inhibition on anterior swim...
The data set provides all data that were reported in results, tables, and figures associated with Stinckens et al., "The effect of thyroperoxidase and deiodinase inhibition on... -
An Integrated Approach for Identifying Priority Contaminant in the Great...
Prioritization of chemicals was performed on two Areas of Concerns in the Great Lakes An integrated risk surveillance and monitoring approach was applied Bio-effect prediction... -
Impaired swim bladder inflation in early-life stage fathead minnows exposed...
The present study investigated whether inhibition of deiodinase, the enzyme which converts thyroxine (T4) to the more biologically-active form, 3,5,3'-triiodothyronine (T3),... -
Prioritization of Contaminants of Emerging Concern in Wastewater Treatment...
We examined whether contaminants present in surface waters could be prioritized for further assessment by linking the presence of specific chemicals to gene expression changes... -
Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase...
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme...