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Year-round presence of neonicotinoid insecticides in tributaries to the Great...
To better understand the transport of neonicotinoid insecticides into the Great Lakes, monthly samples (October 2015-September 2016) were collected from 10 tributaries to the... -
Advancing the Adverse Outcome Pathway Concept – An International ‘Horizon Sca...
Our ability to conduct whole organism toxicity tests to understand chemical safety has been outpaced by our ability to synthesize new chemicals for a wide variety of commercial... -
Hypothetical Aggregate Exposure Pathway Network
This data set contains R code for a hypothetical exposure model described in the manuscript "A quantitative source-to-outcome case study to demonstrate the integration of human... -
Assessing reproductive effects of aromatase inhibition on fishes with group-s...
Predictive models and frameworks for linking inhibition of the enzyme aromatase, as measured in non-animal high throughput screening assays, to adverse effects on reproduction... -
Integrative computational approaches to inform relative bioaccumulation poten...
Datasets included in the entry are Results from the US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool and from the... -
Derivation and Evaluation of Putative Adverse Outcome Pathways for Effects of...
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme activity in... -
Characterizing cleft palate toxicants using ToxCast data, chemical structure,...
A data set of 500 chemicals evaluated for their ability to induce cleft palate in animal prenatal developmental studies was compiled from Toxicity Reference Database and the... -
SEQUENCING AND DE NOVO DRAFT ASSEMBLIES OF A FATHEAD MINNOW (Pimpehales prome...
The dataset provides the URLs for accessing the genome sequence data and two draft assemblies as well as fathead minnow genotyping data associated with estimating the... -
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and ...
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase... -
Targeted pathway-based in vivo testing using thyroperoxidase inhibition to ev...
These data are represented in tables and graphs in the article, "Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a... -
Case study in 21st century ecotoxicology: using in vitro aromatase inhibitio...
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo)... -
Effects-based monitoring of bioactive contaminants discharged to the Colorado...
The present study highlights the utility of bioeffects-based monitoring in conjunction with analytical chemical measurements of surface waters on the Colorado River associated... -
Larval fathead minnow swim bladder inflation following exposure to 2-mercapto...
In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in... -
In vivo and In vitro neurochemical-based assessments of wastewater effluents ...
All primary data reported in this paper were generated by non-federal collaborators from the University of Michigan and McGill University. US EPA-ORD personnel collected and... -
Maumee River 2012 and 2016
The Maumee River and associated tributaries are an example of a system influenced by a mosaic of contaminant inputs from point and nonpoint sources along a gradient of land... -
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pime...
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation for the three... -
In silico site-directed mutagenesis informs species-specific predictions of c...
All data associated with publication are publicly available online at https://datadryad.org/ by searching doi:10.5061/dryad.2tg6967 Upon accessing data on datadryad.org: Data... -
Quantitative response-response relationships linking aromatase inhibition to ...
Data used in the creation of each figure and table cited in Doering et al. (2019; DOI: 10.1021/acs.est.9b02606) are provided. This dataset is associated with the following... -
Contaminants in bald eagles of the upper Midwestern U.S.: A framework for pri...
Contaminant data from bald eagles in the Upper-Midwest of the US. Dataset contains five tables in total including details of sample collection locations, organic contaminant... -
Identifying chemicals and mixtures of potential biological concern detected i...
Water-borne contaminants were monitored in 69 tributaries of the Laurentian Great Lakes in 2010 and 2014 using semipermeable membrane devices (SPMDs), and polar organic chemical...