Opinion: The clinical use of selective digestive decontamination
type: Dataset
description: Several recent meta-analyses have shown that the use of SDD can reduce the occurrence of nosocomial pneumonia among ventilated patients in the intensive care unit (ICU) setting. However, the use of SDD has also been demonstrated to increase subsequent patient colonization and infection with antibiotic-resistant bacteria, particularly Gram-positive cocci. Therefore, the routine use of SDD cannot be advocated at the present time. The mortality benefit of SDD appears to occur in surgical/trauma patients, and to be associated primarily with the administration of parenteral antibiotics. This is already an accepted practice in most patients during the perioperative period (eg prophylactic parenteral antibiotics for 24 h). Prolonged decontamination of the aerodigestive tract with topical antimicrobials does not appear to influence outcome, and should not be routinely employed.
issued: 2025-07-14
modified: 2025-09-06
contact point: Organization
  fn: NIH
keyword: AmeriGEO
keyword: AmeriGEOSS
keyword: CKAN
keyword: GEO
keyword: GEOSS
keyword: National
keyword: North America
keyword: United States
keyword: antibiotic-resistance
keyword: icu-patients
keyword: nih
keyword: nosocomial-pneumonia
keyword: selective-digestive-decontamination
theme: {NIH}

Official Government Data Source
type: Distribution
description: Visit the original government dataset for complete information, documentation, and data access.
format: HTML
issued: 2025-07-24T09:49:21.754184
modified: 2025-09-23T17:51:24.330690
access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137259/
media type: text/html

US Migrating
type: Agent