This is a dataset accompanying the 2017 publication “Assessing the efficacy of corn-based bait containing antimycin-a to control common carp populations using laboratory and pond experiments.” Data are included for the four experiments conducted described in this paper. First, data for a gavage experiment including mortality of carp per tank, fish metrics (lengths and weights), and water quality data (pH, dissolved oxygen, temperature). Second, data are included for the leaching trial including mortality of bluegill and carp, concentrations of antimycin in the tanks, fish metrics, and water quality metrics. Third, data are included for the species-specificity indoor trial. Included in this are mortality and sample size data, fish metrics, and water quality metrics. Last, data are included for the species-specificity outdoor trial. Included in this are mortality and survival data, fish metrics, and water quality metrics.