Model input data in InputData.xls. Table and figure data in stored_results.xls. This dataset is associated with the following publication: Burkhardt, J., B. Burkhart, and F. Shang. Modeling Nicotine-Induced Chlorine Loss in Drinking Water Using Updated EPANET-MSX. JOURNAL OF ENVIRONMENTAL ENGINEERING. American Society of Civil Engineers (ASCE), Reston, VA, USA, 149(12): 04023086, (2023).