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Mass-spectrometric identification of cyclic phenone metabolites produced by...
Dataset consists of 2 main files as follows: 1. All main and Supplemental MS final figures used for manuscript preparation for better viewing (pdf file). Figures are copies of... -
Effects of early life stage exposure of largemouth bass to atrazine or a...
Largemouth base histological development and transcriptomic changes in gonad tissue after early life stage exposure to Atrazine... -
Male Fathead Minnow Transcriptomes and Associated Chemical Analytes in...
This dataset presents the full hepatic transcriptomes of fathead minnows (Pimephales promelas) caged for four days at multiple sites within the Milwaukee Estuary area of concern... -
Contaminants in bald eagles of the upper Midwestern U.S.: A framework for...
Contaminant data from bald eagles in the Upper-Midwest of the US. Dataset contains five tables in total including details of sample collection locations, organic contaminant... -
High-throughput AR dimerization assay identifies androgen disrupting...
Repository for supplemental files and code for paper titled "High-throughput AR Dimerization Assay Identifies Androgen Disrupting Chemicals and Metabolites", 2022. This dataset... -
Prioritization of chemicals for effects on steroidogenesis using an...
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were downloaded... -
Adverse Outcome Pathway Networks II: Network Analytics
The data set provides a set of txt files and cytoscape files that were used to construct the example AOP networks included in the paper. Additionally, a supplementary table file... -
Predicting Estrogenicity of a Group of Substituted Phenols_IATA
Data are summarized in a two-dimensional data matrix that was developed for each substance for hazard characterization (Tables S1–S3). In the horizontal direction of the matrix,... -
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators...
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium. This dataset is associated with the following... -
Effects of metformin and its metabolite guanylurea on fathead minnow...
Data associated with exposures of fathead minnows to varying concentrations of metformin and/or guanylurea. Includes three individual studies: ex vivo steroidogenesis assay, 96... -
The effect of thyroperoxidase and deiodinase inhibition on anterior swim...
The data set provides all data that were reported in results, tables, and figures associated with Stinckens et al., "The effect of thyroperoxidase and deiodinase inhibition on... -
Impaired swim bladder inflation in early-life stage fathead minnows exposed...
The present study investigated whether inhibition of deiodinase, the enzyme which converts thyroxine (T4) to the more biologically-active form, 3,5,3'-triiodothyronine (T3),... -
Limited chemical structural diversity found to modulate thyroid hormone...
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active... -
Cross-species comparison of chemical inhibition of human and Xenopus...
Supplementary materials for "Olker JH, Korte JJ, Haselman JT, Hornung MW, Degitz SJ. Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine... -
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
Data from a large-scale modeling project called CERAPP (Collaborative Estrogen Receptor Activity Prediction Project) demonstrating using predictive computational models on high-... -
Prioritization of Contaminants of Emerging Concern in Wastewater Treatment...
We examined whether contaminants present in surface waters could be prioritized for further assessment by linking the presence of specific chemicals to gene expression changes... -
First Generation Annotations for the Fathead Minnow (Pimephales promelas) Genome
The fathead minnow (Pimephales promelas) is a laboratory model organism widely used in regulatory toxicity testing and ecotoxicology research. Despite, the wealth of... -
Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase...
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme... -
Identifying chemicals and mixtures of potential biological concern detected...
Water-borne contaminants were monitored in 69 tributaries of the Laurentian Great Lakes in 2010 and 2014 using semipermeable membrane devices (SPMDs), and polar organic chemical...