Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library

The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active compounds were further characterized using additional orthogonal assays, including mammalian one-hybrid assays, coactivator recruitment assays, and a high-throughput, fluorescent imaging, nuclear receptor translocation assay. Results for the library are available at https://tripod.nih.gov/tox21/samples.

This dataset is associated with the following publication: Paul-Friedman, K., M. Martin, K. Crofton, C. Hsu, S. Sakamuru, J. Zhao, M. Xia, R. Huang, D. Stevreva, V. Soni, L. Varticovski, R. Raziuddin, G. Hager, and K. Houck. Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 127(9): 1-16, (2019).

Data and Resources

Field Value
accessLevel public
bureauCode {020:00}
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
identifier https://doi.org/10.23719/1503082
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2019-03-05
programCode {020:095}
publisher U.S. EPA Office of Research and Development (ORD)
publisher_hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
references {https://doi.org/10.1289/ehp5314}
resource-type Dataset
source_datajson_identifier true
source_hash f741be8b4394f541e93996e3ab80c1a522712bd7
source_schema_version 1.1
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • AmeriGEO
  • AmeriGEOSS
  • CKAN
  • GEO
  • GEOSS
  • National
  • North America
  • United States
  • endocrine-disruption
  • high-throughput-screening
  • high-throughput-toxicology
  • thyroid-hormone-receptors
  • tox21
  • toxcast
isopen False
license_id other-license-specified
license_title other-license-specified
maintainer Keith Houck
maintainer_email houck.keith@epa.gov
metadata_created 2025-09-23T19:39:07.290955
metadata_modified 2025-09-23T19:39:07.290961
notes The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active compounds were further characterized using additional orthogonal assays, including mammalian one-hybrid assays, coactivator recruitment assays, and a high-throughput, fluorescent imaging, nuclear receptor translocation assay. Results for the library are available at https://tripod.nih.gov/tox21/samples. This dataset is associated with the following publication: Paul-Friedman, K., M. Martin, K. Crofton, C. Hsu, S. Sakamuru, J. Zhao, M. Xia, R. Huang, D. Stevreva, V. Soni, L. Varticovski, R. Raziuddin, G. Hager, and K. Houck. Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 127(9): 1-16, (2019).
num_resources 1
num_tags 14
title Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library