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Evaluation of food-relevant chemicals in the ToxCast high-throughput screenin...
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the food-relevant... -
Predict_Organ_Toxicity_ChemResTox_Data
We use a supervised machine learning strategy to systematically investigate the relative importance of study type, machine learning algorithm, and type of descriptor on... -
MMartin_DFiler_tcpl: the ToxCast pipeline for high-throughput screening data
The tcpl package provides a set of tools for processing and modeling high-throughput and high-content chemical screening data. This dataset is associated with the following... -
Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern. We... -
Prioritization of chemicals for effects on steroidogenesis using an integrate...
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were downloaded... -
Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Act...
Chemical toxicity can arise from disruption of specific biomolecular functions or through more generalized cell stress and cytotoxicity-mediated processes. Here, concentration-... -
High-throughput screening of chemical effects on steroidogenesis using H295R ...
Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-throughput assay... -
Limited chemical structural diversity found to modulate thyroid hormone recep...
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active...