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Analysis of the myosins encoded in the recently completed
Background Three types of molecular motors play an important role in the organization, dynamics and transport processes associated with the cytoskeleton. The myosin family of... -
Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid...
Background Elevated intracranial pressure (ICP) resulting from impaired drainage of cerebrospinal fluid (CSF) causes hydrocephalus with damage to the central nervous system.... -
Accurate normalization of real-time quantitative RT-PCR data by geometric ave...
Using real-time reverse transcription PCR ten housekeeping genes from different abundance and functional classes in various human tissues were evaluated. The conventional use of... -
Worldwide trends in mortality from biliary tract malignancies
Background Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is... -
An algorithm for mapping positively selected members of quasispecies-type vir...
Background Many RNA viruses do not have a single, representative genome but instead form a set of related variants that has been called a quasispecies. The sequence variability... -
P-ANCA vasculitic neuropathy with 12-year latency between onset of neuropathy...
Background The differential diagnosis of chronic progressive multifocal asymmetric neuropathies is challenging. Vasculitic neuropathies, multifocal forms of chronic inflammatory... -
FastGroup: A program to dereplicate libraries of 16S rDNA sequences
Background Ribosomal 16S DNA sequences are an essential tool for identifying and classifying microbes. High-throughput DNA sequencing now makes it economically possible to... -
Morgenröthe or business as usual: a personal account of the 2nd Annual EULAR ...
The 2nd Annual European League Against Rheumatism (EULAR) Congress, held in Prague, 13–16 June 2001, was an impressive event with a record turnout of 8300 delegates. It offered... -
A PCR-mutagenesis strategy for rapid detection of mutations in codon 634 of the
Background Multiple endocrine neoplasias type 2A (MEN 2A) is a dominantly inherited cancer syndrome. Missence mutations in the codon encoding cysteine 634 of the ret proto-... -
The role of Serine Proteases and Serine Protease Inhibitors in the migration ...
Background Mechanisms regulating neuronal migration during development remain largely undefined. Extracellular matrix cues, target site released factors, and components of the... -
Dorsal horn-enriched genes identified by DNA microarray, in situ hybridizatio...
Background Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the... -
Debate: When should we intervene in unstable angina - Time for an old look?
Current treatment modalities for patients with acute coronary syndromes center on early diagnosis, risk stratification and, increasingly, early treatment including invasive... -
Gene conversion homogenizes the CMT1A paralogous repeats
Background Non-allelic homologous recombination between paralogous repeats is increasingly being recognized as a major mechanism causing both pathogenic microdeletions and... -
Early response genes induced in chondrocytes stimulated with the inflammatory...
Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These... -
Physiological function of the maltose operon regulator, MalR, in
Background Maltose metabolism is initiated by an ATP-dependent permease system in Lactococcus lactis. The subsequent degradation of intracellular maltose is performed by the... -
β1 integrins show specific association with CD98 protein in low density membr...
Background The CD98 (4F2, FRP-1) is a widely expressed cell surface protein heterodimer composed of a glycosylated heavy chain and a non-glycosylated light chain. Originally... -
Kinesins in the Arabidopsis genome: A comparative analysis among eukaryotes
Background Kinesins constitute a superfamily of microtubule motor proteins that are found in eukaryotic organisms. Members of the kinesin superfamily perform many diverse... -
Should all patients receive dual chamber pacing ICDs? The rationale for the D...
All of the prospective multicenter trials that support the use of implantable defibrillators have used single chamber pacemakers/implantable cardiovertor defibrillators (ICDs).... -
Functional group interactions of a 5-HT
Background Lerisetron, a competitive serotonin type 3 receptor (5-HT3R) antagonist, contains five functional groups capable of interacting with amino acids in the 5-HT3R binding... -
Viruses, dendritic cells and the lung
The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but...