Worldwide trends in mortality from biliary tract malignancies

Background Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies.

      Methods
      Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates.


      Results
      An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 ± 1.5, and for females was 5.1 ± 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 ± 0.4 for males, but -1.3 ± 0.4 for females.


      Conclusions
      There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.

Data and Resources

Field Value
accessLevel public
bureauCode {009:25}
catalog_@context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
catalog_@id https://healthdata.gov/data.json
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
catalog_describedBy https://project-open-data.cio.gov/v1.1/schema/catalog.json
identifier https://healthdata.gov/api/views/mxmu-gm3u
issued 2025-07-14
landingPage https://healthdata.gov/d/mxmu-gm3u
modified 2025-09-06
programCode {009:034}
publisher National Institutes of Health
resource-type Dataset
source_datajson_identifier true
source_hash 2380a70ea0fa6bdd83605d46f84599d0923f3a72c9fd8c098cf5a9a376bea53f
source_schema_version 1.1
theme {NIH}
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • AmeriGEO
  • AmeriGEOSS
  • CKAN
  • GEO
  • GEOSS
  • National
  • North America
  • United States
  • biliary-cancer-mortality
  • cholangiocarcinoma-trends
  • liver-cancer
  • mortality-rates
  • nih
isopen False
license_id notspecified
license_title License not specified
maintainer NIH
maintainer_email info@nih.gov
metadata_created 2025-09-23T16:47:08.361868
metadata_modified 2025-09-23T16:47:08.361874
notes Background Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies. Methods Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates. Results An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 ± 1.5, and for females was 5.1 ± 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 ± 0.4 for males, but -1.3 ± 0.4 for females. Conclusions There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.
num_resources 1
num_tags 13
title Worldwide trends in mortality from biliary tract malignancies