Expression data from drosophila melanogaster

Space travel presents unlimited opportunities for exploration and discovery but requires a more complete understanding of the immunological consequences of long-term exposure to the conditions of spaceflight. To understand these consequences better and to contribute to design of effective countermeasures we used the Drosophila model to compare innate immune responses to bacteria and fungi in flies that were either raised on earth or in outer space aboard the NASA Space Shuttle Discovery (STS-121). Microarrays were used to characterize changes in gene expression that occur in response to infection by bacteria and fungus in drosophila that were either hatched and raised in outer space (microgravity) or on earth (normal gravity). Whole Oregon R strain drosophila melanogaster fruit flies either raised on earth or in space that were (1) uninfected (2) infected with bacteria (Escherichia coli) or (3) infected with fungus (Beauveria bassiana) were used for RNA extraction and hybridization on Affymetrix microarrays.

Data and Resources

Field Value
accessLevel public
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identifier nasa_genelab_GLDS-1
issued 2018-06-26
landingPage https://data.nasa.gov/d/4ji5-bx4g
modified 2020-01-29
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Groups
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Tags
  • absorbed-radiation-dose
  • amerigeo
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  • array-scanning-protocol
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  • hybridization-protocol
  • infection
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  • nucleic-acid-extraction-protocol
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  • radiation-detection
  • radiation-dosimetry
  • space-flight
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metadata_created 2025-11-21T00:32:10.240181
metadata_modified 2025-11-21T00:32:10.240184
notes Space travel presents unlimited opportunities for exploration and discovery but requires a more complete understanding of the immunological consequences of long-term exposure to the conditions of spaceflight. To understand these consequences better and to contribute to design of effective countermeasures we used the Drosophila model to compare innate immune responses to bacteria and fungi in flies that were either raised on earth or in outer space aboard the NASA Space Shuttle Discovery (STS-121). Microarrays were used to characterize changes in gene expression that occur in response to infection by bacteria and fungus in drosophila that were either hatched and raised in outer space (microgravity) or on earth (normal gravity). Whole Oregon R strain drosophila melanogaster fruit flies either raised on earth or in space that were (1) uninfected (2) infected with bacteria (Escherichia coli) or (3) infected with fungus (Beauveria bassiana) were used for RNA extraction and hybridization on Affymetrix microarrays.
num_resources 1
num_tags 23
title Expression data from drosophila melanogaster