Gene expression profiling of C. elegans under various thermal conditions

To realistically evaluate the effects of the environment in space it is necessary to understand the effects of external factors during sample transport from Earth to space. The present study focused on temperature profiling the altered gene expression that develops under low cultivation temperatures in C. elegans used as a space life science model. The 7903 genes were selected as differentially expressed genes and divided into five sets with similar expression patterns using k-means clustering. Results from Gene Ontology analysis are significantly indicated that the cell cycle related genes and the TGF?/insulin-like signal pathway related genes changed. The TGF?/insulin-like signal pathway is expected to be activated due to low temperatures as well as by other stressors. To determine the genes whose expression changed four thermal conditions (10 15 20 and 25 xa1C) DNA microarray analysis was performed. The data consisted of 12 samples consisting of three biological replicates at each temperature.

Data and Resources

Field Value
accessLevel public
accrualPeriodicity irregular
bureauCode {026:00}
catalog_@context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
catalog_describedBy https://project-open-data.cio.gov/v1.1/schema/catalog.json
identifier nasa_genelab_GLDS-40_sebd-hw92
issued 2018-06-26
landingPage https://data.nasa.gov/dataset/gene-expression-profiling-of-c-elegans-under-various-thermal-conditions
modified 2025-04-23
programCode {026:005}
publisher National Aeronautics and Space Administration
resource-type Dataset
source_datajson_identifier true
source_hash 8972e0e4c7b5d57b93dd2093a8364fde25f6d278d0c78254bd6ee00de89afb7d
source_schema_version 1.1
theme {"Earth Science"}
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • AmeriGEO
  • AmeriGEOSS
  • CKAN
  • GEO
  • GEOSS
  • National
  • North America
  • United States
  • bioassay_data_transformation
  • feature_extraction
  • grow
  • hybridization
  • image_aquisition
  • labeling
  • p-gse14475-1
  • p-gse14475-2
  • p-gse14475-4
  • p-gse14475-5
  • p-gse14475-6
  • p-gse14475-7
  • temperature
isopen False
license_id notspecified
license_title License not specified
maintainer GeneLab Outreach
maintainer_email genelab-outreach@lists.nasa.gov
metadata_created 2025-09-24T05:56:10.925410
metadata_modified 2025-09-24T05:56:10.925419
notes To realistically evaluate the effects of the environment in space it is necessary to understand the effects of external factors during sample transport from Earth to space. The present study focused on temperature profiling the altered gene expression that develops under low cultivation temperatures in C. elegans used as a space life science model. The 7903 genes were selected as differentially expressed genes and divided into five sets with similar expression patterns using k-means clustering. Results from Gene Ontology analysis are significantly indicated that the cell cycle related genes and the TGF?/insulin-like signal pathway related genes changed. The TGF?/insulin-like signal pathway is expected to be activated due to low temperatures as well as by other stressors. To determine the genes whose expression changed four thermal conditions (10 15 20 and 25 xa1C) DNA microarray analysis was performed. The data consisted of 12 samples consisting of three biological replicates at each temperature.
num_resources 1
num_tags 21
title Gene expression profiling of C. elegans under various thermal conditions