Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls

The experimental data were taken from Simon et al., who compiled potency data for effects related to neurotoxicity from four experimental datasets, Stenberg et al. [18] and Wigestrand et al. The measures of potency were EC50 (µM) or IC50 values for all the effects except Stenberg data, which were expressed as a percentage of the control uptake for different concentrations measured.

This dataset is associated with the following publication: Pradeep, P., L. Carlson, R. Judson, G. Lehmann, and G. Patlewicz. Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 101: 12-23, (2019).

Data and Resources

Field Value
accessLevel public
bureauCode {020:00}
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
identifier https://doi.org/10.23719/1503181
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2018-08-22
programCode {020:095}
publisher U.S. EPA Office of Research and Development (ORD)
publisher_hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
references {https://doi.org/10.1016/j.yrtph.2018.10.013}
resource-type Dataset
source_datajson_identifier true
source_hash 3b9cfed19a4a283a973e7d1b1bfc98b34455ab82
source_schema_version 1.1
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • AmeriGEO
  • AmeriGEOSS
  • CKAN
  • GEO
  • GEOSS
  • National
  • North America
  • United States
  • dsstox
  • neurotoxic-equivalent-factor-nef
  • neurotoxicity
  • pcb-congeners
  • qsar
  • toxic-equivalency-factors-tefs
isopen False
license_id other-license-specified
license_title other-license-specified
maintainer Ann Richard
maintainer_email richard.ann@epa.gov
metadata_created 2025-09-24T08:28:31.989736
metadata_modified 2025-09-24T08:28:31.989746
notes The experimental data were taken from Simon et al., who compiled potency data for effects related to neurotoxicity from four experimental datasets, Stenberg et al. [18] and Wigestrand et al. The measures of potency were EC50 (µM) or IC50 values for all the effects except Stenberg data, which were expressed as a percentage of the control uptake for different concentrations measured. This dataset is associated with the following publication: Pradeep, P., L. Carlson, R. Judson, G. Lehmann, and G. Patlewicz. Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 101: 12-23, (2019).
num_resources 4
num_tags 14
title Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls