MHC class I multimers

T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively the specificity, frequency and intensity of T cell responses. The recent application of fluorescent-labelled MHC class I multimers, however, has provided a powerful experimental approach to the direct visualisation of antigen-specific T cells. As a result, our perspective of how T cells respond to both viruses and other antigens in vivo has been greatly enhanced.

Data and Resources

Field Value
accessLevel public
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identifier https://healthdata.gov/api/views/khzh-m9pm
issued 2025-07-14
landingPage https://healthdata.gov/d/khzh-m9pm
modified 2025-09-06
programCode {009:048}
publisher National Institutes of Health
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Groups
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  • National Provider
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Tags
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  • National
  • North America
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  • antigen-specific-t-cells
  • immune-response
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  • t-lymphocytes
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license_id notspecified
license_title License not specified
maintainer NIH
maintainer_email info@nih.gov
metadata_created 2025-09-24T21:11:09.598474
metadata_modified 2025-09-24T21:11:09.598486
notes T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively the specificity, frequency and intensity of T cell responses. The recent application of fluorescent-labelled MHC class I multimers, however, has provided a powerful experimental approach to the direct visualisation of antigen-specific T cells. As a result, our perspective of how T cells respond to both viruses and other antigens in vivo has been greatly enhanced.
num_resources 1
num_tags 13
title MHC class I multimers