The airport catchment area is the geographic area from which an airport can reasonably expect to draw commercial air service passengers. The purpose of this interdisciplinary research is to estimate airport catchment areas using a spatial analysis method for informed airport management. In order to ensure the comprehensiveness and reliability of the research, we chose to analyze the catchment areas for five airports of different sizes and in different geographic locations in the United States. The Huff model, which is usually used in marketing, economics, and retail research, was adopted in this study. We applied this model in airport catchment analysis for the selected airports, with consideration of ground transportation distance and airport attractiveness. We identified the best distance factors and parameters for modeling purposes. The results provided reliable information for the selected five airports to estimate their catchment areas. In addition, the model can provide a good reference for other airport catchment analysis studies about the effectiveness of the Huff model in prediction.