(REPRODUCTIVE TOXICOLOGY) EMBRYONIC VASCULAR DISRUPTION ADVERSE OUTCOMES: LINKING HIGH THROUGHPUT SIGNALING SIGNATURES WITH FUNCTIONAL CONSEQUENCES

This study evaluated two anti-angiogenic agents, 5HPP-33 and TNP-470, across the ToxCastDB HTS assay platform and anchored the results to complex in vitro functional assays: the rat aortic explant assay (AEA), rat whole embryo culture (WEC), and the zebrafish embryotoxicity (ZET) assay. This dataset is not publicly accessible because: no EPA data; all the data generated by external organizations; EPA coauthors. It can be accessed through the following means: Data generated by external organizations. Format: N/A.

This dataset is associated with the following publication: Ellis-Hutchings, R., R. Settivari, A. McCoy, N. Kleinstreuer, J. Franzosa, T. Knudsen, and E. Carney. (REPRODUCTIVE TOXICOLOGY) EMBRYONIC VASCULAR DISRUPTION ADVERSE OUTCOMES: LINKING HIGH THROUGHPUT SIGNALING SIGNATURES WITH FUNCTIONAL CONSEQUENCES. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 70: 82-96, (2017).

Data and Resources

This dataset has no data

Field Value
accessLevel public
bureauCode {020:00}
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
identifier https://doi.org/10.23719/1505448
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2017-06-01
programCode {020:095}
publisher U.S. EPA Office of Research and Development (ORD)
publisher_hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
references {https://doi.org/10.1016/j.reprotox.2017.05.005}
resource-type Dataset
source_datajson_identifier true
source_hash d882ca6f9f685c3508875e9a5f17e86f56535b7e
source_schema_version 1.1
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • amerigeo
  • amerigeoss
  • ckan
  • expocast
  • exposure
  • geo
  • geoss
  • national
  • north-america
  • united-states
isopen False
license_id other-license-specified
license_title other-license-specified
maintainer Alexander Hanf
maintainer_email hanf.alexander@epa.gov
metadata_created 2025-11-21T14:02:22.581666
metadata_modified 2025-11-21T14:02:22.581671
notes This study evaluated two anti-angiogenic agents, 5HPP-33 and TNP-470, across the ToxCastDB HTS assay platform and anchored the results to complex in vitro functional assays: the rat aortic explant assay (AEA), rat whole embryo culture (WEC), and the zebrafish embryotoxicity (ZET) assay. This dataset is not publicly accessible because: no EPA data; all the data generated by external organizations; EPA coauthors. It can be accessed through the following means: Data generated by external organizations. Format: N/A. This dataset is associated with the following publication: Ellis-Hutchings, R., R. Settivari, A. McCoy, N. Kleinstreuer, J. Franzosa, T. Knudsen, and E. Carney. (REPRODUCTIVE TOXICOLOGY) EMBRYONIC VASCULAR DISRUPTION ADVERSE OUTCOMES: LINKING HIGH THROUGHPUT SIGNALING SIGNATURES WITH FUNCTIONAL CONSEQUENCES. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 70: 82-96, (2017).
num_resources 0
num_tags 10
title (REPRODUCTIVE TOXICOLOGY) EMBRYONIC VASCULAR DISRUPTION ADVERSE OUTCOMES: LINKING HIGH THROUGHPUT SIGNALING SIGNATURES WITH FUNCTIONAL CONSEQUENCES