Sex-specific respiratory and systemic stress effects of acute acrolein and trichloroethylene inhalation

Employing acrolein, a potent airway irritant, and TCE, with low irritancy, authors hypothesized that airway injury and inflammation would be involved in eliciting neuroendocrine-mediated systemic alterations. Male and female Wistar-Kyoto rats were exposed nose-only to air, acrolein or trichloroethylene (TCE) in incremental concentrations over 30 min, followed by 3.5-hr exposure to the highest concentration (acrolein - 0.0, 0.1, 0.316, 1, 3.16 ppm; TCE - 0.0, 3.16, 10, 31.6, 100 ppm) while performing head-out plethysmography (HOP), and animals were necropsied immediately post-exposure to assess nasal and lung injury/inflammation, systemic neurohormones, circulating stress hormones and also metabolic hormones.

This dataset is associated with the following publication: Alewel, D., T. Jackson, S. Vance, M. Schladweiler, P. Evansky, A. Henriquez, R. Grindstaff, S. Gavett, and U. Kodavanti. Sex-specific respiratory and systemic endocrine effects of acute acrolein and trichloroethylene inhalation. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 382: 22-32, (2023).

Data and Resources

Field Value
accessLevel public
bureauCode {020:00}
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
identifier https://doi.org/10.23719/1528189
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2022-11-07
programCode {020:000}
publisher U.S. EPA Office of Research and Development (ORD)
publisher_hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
references {https://doi.org/10.1016/j.toxlet.2023.05.005}
resource-type Dataset
source_datajson_identifier true
source_hash 10b6f5b458f78c091fb7fc61b4978ea0a1f14dd1808f15eb5086d7b48095e9b7
source_schema_version 1.1
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • AmeriGEO
  • AmeriGEOSS
  • CKAN
  • GEO
  • GEOSS
  • National
  • North America
  • United States
  • acrolein
  • air-pollution
  • ambient-air
  • nitrogen-and-co-pollutants
  • sex-difference
  • trichloroethylene
isopen False
license_id other-license-specified
license_title other-license-specified
maintainer Urmila Kodavanti
maintainer_email kodavanti.urmila@epa.gov
metadata_created 2025-09-24T08:39:02.865102
metadata_modified 2025-09-24T08:39:02.865111
notes Employing acrolein, a potent airway irritant, and TCE, with low irritancy, authors hypothesized that airway injury and inflammation would be involved in eliciting neuroendocrine-mediated systemic alterations. Male and female Wistar-Kyoto rats were exposed nose-only to air, acrolein or trichloroethylene (TCE) in incremental concentrations over 30 min, followed by 3.5-hr exposure to the highest concentration (acrolein - 0.0, 0.1, 0.316, 1, 3.16 ppm; TCE - 0.0, 3.16, 10, 31.6, 100 ppm) while performing head-out plethysmography (HOP), and animals were necropsied immediately post-exposure to assess nasal and lung injury/inflammation, systemic neurohormones, circulating stress hormones and also metabolic hormones. This dataset is associated with the following publication: Alewel, D., T. Jackson, S. Vance, M. Schladweiler, P. Evansky, A. Henriquez, R. Grindstaff, S. Gavett, and U. Kodavanti. Sex-specific respiratory and systemic endocrine effects of acute acrolein and trichloroethylene inhalation. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 382: 22-32, (2023).
num_resources 1
num_tags 14
title Sex-specific respiratory and systemic stress effects of acute acrolein and trichloroethylene inhalation