Urinary miRNAs measured in rat studies associated with nephron-specific chemical toxicity

Urine samples were derived from a variety of archived industry-led studies, outlined in the dataset. The purpose was to measure a targeted set of miRNA targets that were represented in the Thermo Fisher TLDA A and TLDA B card sets in Figure 2. These case studies were selected due to probable nephrotoxicity, associated with published or internal records. These clinical markers and histopath evidence was included in Table 1 associated dataset. Given specific nephron toxicity, this experiment would determine miRNA candidates that may be specific toxicity biomarkers. This analysis set up the Venn Analysis in Figure 3, which specified candidates for nephron-specific analyses.

This dataset is associated with the following publication: Chorley, B., H. Ellinger-Ziegelbauer, M. Tackett, F. Simutis, A. Harrill, J. McDuffie, E. Atabakhsh, R. Nassirpour, L. Whiteley, J. Léonard, G. Carswell, E. Harpur, C. Chen, and J. Gautier. Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 180(1): 1-16, (2021).

Data and Resources

Field Value
accessLevel public
bureauCode {020:00}
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
identifier https://doi.org/10.23719/1518921
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2020-06-23
programCode {020:095}
publisher U.S. EPA Office of Research and Development (ORD)
publisher_hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
references {https://doi.org/10.1093/toxsci/kfaa181}
resource-type Dataset
source_datajson_identifier true
source_hash be861aaef4f0bf9f6e6be7bbdff015aeaacd769d
source_schema_version 1.1
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • amerigeo
  • amerigeoss
  • biomarkers
  • ckan
  • geo
  • geoss
  • kidney-injury
  • micrornas
  • national
  • north-america
  • safety-assessment
  • united-states
isopen False
license_id other-license-specified
license_title other-license-specified
maintainer Brian Chorley
maintainer_email chorley.brian@epa.gov
metadata_created 2025-11-21T23:48:44.346763
metadata_modified 2025-11-21T23:48:44.346768
notes Urine samples were derived from a variety of archived industry-led studies, outlined in the dataset. The purpose was to measure a targeted set of miRNA targets that were represented in the Thermo Fisher TLDA A and TLDA B card sets in Figure 2. These case studies were selected due to probable nephrotoxicity, associated with published or internal records. These clinical markers and histopath evidence was included in Table 1 associated dataset. Given specific nephron toxicity, this experiment would determine miRNA candidates that may be specific toxicity biomarkers. This analysis set up the Venn Analysis in Figure 3, which specified candidates for nephron-specific analyses. This dataset is associated with the following publication: Chorley, B., H. Ellinger-Ziegelbauer, M. Tackett, F. Simutis, A. Harrill, J. McDuffie, E. Atabakhsh, R. Nassirpour, L. Whiteley, J. Léonard, G. Carswell, E. Harpur, C. Chen, and J. Gautier. Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 180(1): 1-16, (2021).
num_resources 3
num_tags 12
title Urinary miRNAs measured in rat studies associated with nephron-specific chemical toxicity