In vitro intestinal toxicity of cppper oxide nanoparticles in rat and human models

Dose response viability data of rat and human intestinal cells exposed to copper oxide nanoparticles (CuO, Cu2O), CuSO4 and CuCl (rat cells only). Assays examining a potential mechanism of toxicity were included (generation of H2O2 and loss of GSH) and the effect on mitochondria. Dissolution of CuO and Cu2O nanoparticles was also examined.

This dataset is associated with the following publication: Henson, T., J. Navratilova, A. Tennant, K. Bradham, K. Rogers, and M. Hughes. In vitro intestinal toxicity of copper oxide nanoparticles in rat and human cell models. Nanotoxicology. Informa Healthcare, London, UK, 13(6): 795-811, (2019).

Data and Resources

Field Value
accessLevel public
bureauCode {020:00}
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
identifier https://doi.org/10.23719/1504038
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2019-07-03
programCode {020:095}
publisher U.S. EPA Office of Research and Development (ORD)
publisher_hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
references {https://doi.org/10.1080/17435390.2019.1578428}
resource-type Dataset
source_datajson_identifier true
source_hash 49183c4c4f9a64fa6bc9482050cc98a6a01c710c
source_schema_version 1.1
Groups
  • AmeriGEOSS
  • National Provider
  • North America
Tags
  • AmeriGEO
  • AmeriGEOSS
  • CKAN
  • GEO
  • GEOSS
  • National
  • North America
  • United States
  • copper
  • copper-nanoparticles
  • cytotoxicity
  • in-vitro
  • intesine
isopen False
license_id other-license-specified
license_title other-license-specified
maintainer Michael Hughes
maintainer_email hughes.michaelf@epa.gov
metadata_created 2025-09-24T20:01:03.806410
metadata_modified 2025-09-24T20:01:03.806420
notes Dose response viability data of rat and human intestinal cells exposed to copper oxide nanoparticles (CuO, Cu2O), CuSO4 and CuCl (rat cells only). Assays examining a potential mechanism of toxicity were included (generation of H2O2 and loss of GSH) and the effect on mitochondria. Dissolution of CuO and Cu2O nanoparticles was also examined. This dataset is associated with the following publication: Henson, T., J. Navratilova, A. Tennant, K. Bradham, K. Rogers, and M. Hughes. In vitro intestinal toxicity of copper oxide nanoparticles in rat and human cell models. Nanotoxicology. Informa Healthcare, London, UK, 13(6): 795-811, (2019).
num_resources 1
num_tags 13
title In vitro intestinal toxicity of cppper oxide nanoparticles in rat and human models