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Gene responses in mouse brain to long-term exposure to microgravity
The spaceflight experiment was carried out using male C57BL/10J mice (8 weeks old at launch). Wild type mice (n=3) were launched by Space Shuttle Discovery and housed on the... -
Radiation responses in peripheral white blood cells of smokers and non-smokers
Understanding the possible impact of potential confounding factors is necessary for any approach to radiation biodosimetry. Potential confounding factors have not been fully... -
MESSAGE 2 space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid agar rich media was sent to the ISS in October 2003 (MESSAGE-part 2 experiment). After 10 days flight R. rubrum cultures returned back to... -
Root transcriptome remodeling of Arabidopsis in response to high levels of ma...
Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars. However... -
The Arabidopsis spaceflight transcriptome: a comparison of whole plants to di...
Arabidopsis thaliana was evaluated for its response to the spaceflight environment in three replicated experiments on the International Space Station. Two approaches were used;... -
Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model i...
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus... -
Non-targeted effects of low dose ionizing radiation act via TGF-beta to promo...
This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy) 1 and 4 weeks after... -
Low dose ionizing radiation treated lymphoblastoid cells
Irradiated cell lines exposed to 1-10 Gy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 Gy RNA is isolated and labeled using a T7 amplification... -
Response of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity
Anticipating the risk for infectious disease during space exploration and habitation is a critical factor to ensure safety health and performance of the crewmembers. As a... -
Response of human lymphoblastoid cells to activated medium
Transcriptional profiling of human lymphoblastoid TK6 cells comparing mock irradiaed cells resuspended in fresh untreated RPMI 1640 medium with cells resuspended in medium... -
BASE-A space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid minimal media was sent to the ISS in September 2006 (BASE-A experiment). After 10 days flight R. rubrum cultures returned back to Earth. These... -
Transcription profiling of human peripheral blood to development gene express...
To further development of our gene expression approach to biodosimetry we have employed whole genome microarray expression profiling as a discovery platform to identify genes... -
Gene expression profiling of C. elegans under various thermal conditions
To realistically evaluate the effects of the environment in space it is necessary to understand the effects of external factors during sample transport from Earth to space. The... -
Transcription profiling by array of the response of Arabidopsis cultivar Colu...
We address a key baseline question of whether gene expression changes are induced by the orbital environment and then we ask whether undifferentiated cells cells presumably... -
IMR90 4hr bystander experiment 0.5Gy alpha particle strip dish format
Radiation affects tissue and cellular integrity at the level of DNA protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to... -
Identifying radiation exposure biomarkers from mouse blood transcriptome
Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological samples... -
Gene responses in mouse brain to long-term exposure to microgravity
The spaceflight experiment was carried out using male C57BL/10J mice (8 weeks old at launch). Wild type mice (n=3) were launched by Space Shuttle Discovery and housed on the... -
The Arabidopsis spaceflight transcriptome: a comparison of whole plants to di...
Arabidopsis thaliana was evaluated for its response to the spaceflight environment in three replicated experiments on the International Space Station. Two approaches were used;... -
Gene expression profiling of C. elegans under various thermal conditions
To realistically evaluate the effects of the environment in space it is necessary to understand the effects of external factors during sample transport from Earth to space. The... -
Effect of simulated microgravity on E. coli K12 MG1655 growth and gene expres...
This study demonstrates simulated microgravity effects on E. coli K 12 MG1655 when grown on LB medium supplemented with glycerol. The results imply that E. coli readily...
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