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Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most... -
Proton Irradiation Impacts Age Driven Modulations of Cancer Progression Influ...
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological modulations... -
Immediate Transcriptional Changes in Response to High Dose Radiation Exposure
One of the most likely risks astronauts on long duration space missions face is exposure to ionizing radiation associated with highly energetic and charged heavy (HZE)... -
Murine microenvironment metaprofiles associate with human cancer etiology and...
We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene expression... -
Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Co...
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses typical of... -
Effects of spaceflight on murine skeletal muscle gene expression
Spaceflight results in a number of adaptations to skeletal muscle including atrophy and shifts towards faster muscle fiber types. To identify changes in gene expression that may... -
Dynamic gene expression response to altered gravity in human T cells (soundin...
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles to identify... -
Gene Expression Profile Changes due to Bleomycin-Induced DNA Damage in Human ...
To understand gene expression responses in confluent human fibroblast in microgravity conditions to bleomycin treatment. Confluent human fibroblasts AG01522 were flown to the... -
Gene expression response to simulated gravity and hypergravity in human T cells
We investigated differentially regulated and stably expressed genes in human Jurkat T lymphocytic cells in 5min simulated microgravity and hypergravity and compared expression... -
Proton irradiation augments the reduction in tumor progression observed with ...
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that in... -
Synergistic effects of space radiation and microgravity (miRNA WT and ced-1 m...
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA... -
Microgravity effect on C. elegans N2/VC (CERISE 4 days)
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese Module of the... -
Effects of 21 days of bedrest on human skeletal muscle gene expression
The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression. 14 male subjects participated in normoxic bedrest (NBR)... -
Effects of a Closed Space Environment on Gene Expression in Hair Follicles of...
In recent times long-term stay has become a common occurrence in the International Space Station (ISS). However adaptation to the space environment can sometimes pose... -
Delayed Cardiomyocyte Response to Total Body Particle Radiation Exposure - Id...
We examined molecular responses using transcriptome profiling in isolated left ventricular murine cardiomyocytes to 90 cGy 1 GeV proton (1H) and 15 cGy 1 GeV/nucleon (n) iron... -
Transient gene expression profile changes of confluent human fibroblast cells...
Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or animals but... -
Biological and Metabolic Response in STS-135 Space-flown Mouse Skin
Changes in gene expression profiles implicated in oxidative stress and in ECM remodeling in mouse skin were examined after space flight. The metabolic effects of space flight in... -
Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET ...
Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological effectiveness (RBE)... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Co...
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses typical of...
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