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Microbial Observatory (ISS-MO): Study of BSL-2 bacterial isolates from the In...
In an on-going Microbial Observatory experimental investigation on the International Space Station (ISS) multiple bacterial isolates of Biosafety Level 2 (BSL-2) were isolated... -
Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most... -
Proton Irradiation Impacts Age Driven Modulations of Cancer Progression Influ...
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological modulations... -
Microbial Observatory (ISS-MO): Microbial diversity
The environmental microbiome study was designed to decipher microbial diversity of the International Space Station surfaces in terms of spatial and temporal distributions using... -
Rodent Research-3-CASIS: Mouse liver transcriptomic proteomic and epigenomic ...
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
Murine microenvironment metaprofiles associate with human cancer etiology and...
We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene expression... -
Streptococcus mutans differential gene expression in response to simulated mi...
Astronauts have been previously shown to exhibit decreased salivary lysozyme and increased dental calculus and gingival inflammation in response to space flight host factors... -
Rodent Research-3-CASIS: Mouse adrenal gland transcriptomic proteomic and epi...
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
Rodent Research-1 (RR1) NASA Validation Flight: Mouse soleus muscle transcrip...
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources... -
Whole genome sequencing and assembly of Eukaryotic microbes isolated from ISS...
The whole-genome sequences of eight fungal strains that were selected for exposure to microgravity at the International Space Station are presented here. These baseline... -
RNA-seq analysis of mycobacteria stress response to microgravity
The aim of this work is to determine whether mycobacteria have enhanced virulence during space travel and what mechanisms they use to adapt to microgravity. M. marinum and LHM4... -
Effect of microgravity on an animal-bacteria symbiosis
Spaceflight imposes numerous adaptive challenges for terrestrial life. The reduction in gravity or microgravity represents a novel environment that can disrupt homeostasis of... -
Rodent Research-1 (RR1) NASA Validation Flight: Mouse extensor digitorum long...
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources... -
STS-135 Liver Transcriptomics
Mice were flown onboard STS-135 and returned to Earth for analysis. Livers were collected within 3-4 hours of landing and snap frozen in liquid nitrogen. Samples were shipped to... -
Gene Expression Profile Changes due to Bleomycin-Induced DNA Damage in Human ...
To understand gene expression responses in confluent human fibroblast in microgravity conditions to bleomycin treatment. Confluent human fibroblasts AG01522 were flown to the... -
Biomolecule Sequencer
Technology demonstration of a nanopore sequencer operating aboard the ISS in comparison with the same sequencer on the ground. -
Proton irradiation augments the reduction in tumor progression observed with ...
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that in... -
Temporal dynamics of the gut microbiota in people sharing a confined environm...
The MARS500 project the longest ground-based space simulation ever provided us with a unique opportunity to trace the crew microbiota over 520 days of isolated confinement such... -
Synergistic effects of space radiation and microgravity (miRNA WT and ced-1 m...
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA... -
Genes Required for Survival in Microgravity Revealed by Genome-Wide Yeast Del...
Spaceflight is a unique environment with profound effects on biological systems including tissue redistribution and musculoskeletal stresses. However the more subtle biological...
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