The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver

Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, circulating lipids and liver global mRNA expression were assessed. mRNA sequencing data are already made publicly available.

This dataset is associated with the following publication: Colonna, C., A. Henriquez, J. House, A. Motsinger-Reif, D. Alewel, A. Fisher, H. Ren, S. Snow, M.C. Schladweiler, D. Miller, C. Miller, P.R. Kodavanti, and U. Kodavanti. The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 181(2): 229-245, (2021).

Data e Risorse

Campo Valore
accessLevel public
bureauCode {020:00}
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
identifier https://doi.org/10.23719/1521265
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2021-03-22
programCode {020:000}
publisher U.S. EPA Office of Research and Development (ORD)
publisher_hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
references {https://doi.org/10.1093/toxsci/kfab025}
resource-type Dataset
source_datajson_identifier true
source_hash 6ae0823e55e68a9c985d439d167a036b9480b9ec
source_schema_version 1.1
Gruppi
  • AmeriGEOSS
  • National Provider
  • North America
Tag
  • AmeriGEO
  • AmeriGEOSS
  • CKAN
  • GEO
  • GEOSS
  • National
  • North America
  • United States
  • cell-cycle
  • fatty-acid-metabolism
  • glucose-metabolism
  • hepatic-vagotomy
  • liver-mrna-sequencing
  • ozone
  • stress-response
isopen False
license_id other-license-specified
license_title other-license-specified
maintainer Urmila Kodavanti
maintainer_email kodavanti.urmila@epa.gov
metadata_created 2025-09-23T16:12:22.010738
metadata_modified 2025-09-23T16:12:22.010744
notes Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, circulating lipids and liver global mRNA expression were assessed. mRNA sequencing data are already made publicly available. This dataset is associated with the following publication: Colonna, C., A. Henriquez, J. House, A. Motsinger-Reif, D. Alewel, A. Fisher, H. Ren, S. Snow, M.C. Schladweiler, D. Miller, C. Miller, P.R. Kodavanti, and U. Kodavanti. The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 181(2): 229-245, (2021).
num_resources 1
num_tags 15
title The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver