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Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most... -
Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Co...
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses typical of... -
STS-135 Liver Transcriptomics
Mice were flown onboard STS-135 and returned to Earth for analysis. Livers were collected within 3-4 hours of landing and snap frozen in liquid nitrogen. Samples were shipped to... -
Gene Expression Profile Changes due to Bleomycin-Induced DNA Damage in Human ...
To understand gene expression responses in confluent human fibroblast in microgravity conditions to bleomycin treatment. Confluent human fibroblasts AG01522 were flown to the... -
Proton irradiation augments the reduction in tumor progression observed with ...
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that in... -
Synergistic effects of space radiation and microgravity (miRNA WT and ced-1 m...
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA... -
Microgravity effect on C. elegans N2/VC (CERISE 4 days)
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese Module of the... -
Effects of a Closed Space Environment on Gene Expression in Hair Follicles of...
In recent times long-term stay has become a common occurrence in the International Space Station (ISS). However adaptation to the space environment can sometimes pose... -
Transient gene expression profile changes of confluent human fibroblast cells...
Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or animals but... -
Biological and Metabolic Response in STS-135 Space-flown Mouse Skin
Changes in gene expression profiles implicated in oxidative stress and in ECM remodeling in mouse skin were examined after space flight. The metabolic effects of space flight in... -
Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET ...
Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological effectiveness (RBE)... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Co...
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses typical of... -
NSDUH 2012 Methodological Resource Book
This Methodological Resource Book (MRB) is intended to serve as documentation of survey materials and methodology associated with the 2012 National Survey on Drug Use and Health... -
Global gene expression analysis highlights microgravity sensitive key genes i...
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in physiological... -
Katahdin Woods and Waters National Monument Seboeis Unit Accuracy Assessment ...
The Katahdin Woods and Waters National Monument Seboeis Unit Vegetation Mapping Project was initiated in the fall of 2019 by a grant through the USGS Natural Resource... -
2013 NSDUH Data Collection Final Report
NSDUH is funded by the Substance Abuse and Mental Health Services Administration (SAMHSA), an agency of the U.S. Public Health Service in the U.S. Department of Health and Human... -
Katahdin Woods and Waters National Monument Seboeis Unit Vegetation Mapping P...
During summer 2019, botanists with the Maine Natural Areas Program collected data from 94 vegetation plots for plant community characterization. The sampling data were entered... -
Riparian vegetation data downstream of Glen Canyon Dam in Glen Canyon Nationa...
These data were collected by the Grand Canyon Monitoring and Research Center (GCMRC) to support riparian vegetation monitoring along the Colorado River between Glen Canyon Dam... -
The influence of simulated microgravity on the proteome of Daphnia magna
Background/Objectives: The waterflea Daphnia is an interesting candidate for bioregenerative life support systems (BLSS). These animals are particularly promising because of...