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Microgravity effect on C. elegans N2/VC (CERISE 4 days)
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese Module of the... -
Effects of 21 days of bedrest on human skeletal muscle gene expression
The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression. 14 male subjects participated in normoxic bedrest (NBR)... -
Comparison of the spaceflight transcriptome of four commonly used Arabidopsis...
This experiment compared the spaceflight transcriptomes of four commonly used natural variants (ecotypes) of Arabidopsis thaliana using RNAseq. In nature Arabidopsis is a native... -
Validation of Methods to Assess the Immunoglobulin Gene Repertoire in Tissues...
Spaceflight is known to affect immune cell populations. In particular splenic B-cell numbers decrease during spaceflight and in ground-based physiological models. Although... -
Analysis of dust samples from the Russian part of the ISS
Our study focuses on the hardiest microorganisms inhabiting the ISS in order to assess their diversity and capabilities to resist certain stresses. We specifically selected dust... -
Microbial Observatory (ISS-MO): Molecular characterization of Bacillus issens...
As part of an ongoing effort to catalogue microbial communities inhabiting the International Space Station (ISS) crew-associated environmental samples were collected from the... -
Transient gene expression profile changes of confluent human fibroblast cells...
Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or animals but... -
Biological and Metabolic Response in STS-135 Space-flown Mouse Skin
Changes in gene expression profiles implicated in oxidative stress and in ECM remodeling in mouse skin were examined after space flight. The metabolic effects of space flight in... -
Adaptive changes in the vestibular system of land snail to a 30-day spaceflig...
The vestibular system receives a permanent influence from gravity and reflexively controls equilibrium. If we assume gravity has remained constant during the species evolution... -
Rodent Research-3-CASIS: Mouse retina transcriptomic data
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
RR-1 and RR-3 mouse liver transcriptomics with and without ERCC control RNA s...
Proper interpretation of RNA sequencing data requires an understanding of assay sensitivity and sources of variability. To this end the External RNA Control Consortium (ERCC)... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
Spaceflight adaptation requires organ specific alterations in the proteomes o...
Life in spaceflight demonstrates remarkable adaptive processes within the specialized environments of space vehicles which are subject to the myriad of attending and unique... -
Rodent Research-3-CASIS: Mouse kidney transcriptomic proteomic and epigenomic...
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
Global gene expression analysis highlights microgravity sensitive key genes i...
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in physiological... -
International Space Station conditions alter genomics proteomics and metabolo...
The first global genomic proteomic and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space... -
Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic pr...
RR-1 is a validation flight to evaluate the hardware operational and science capabilities of the Rodent Research Project on the ISS. RNA DNA and protein were purified from liver... -
Rodent Research-1 (RR1) NASA Validation Flight: Mouse quadriceps muscle trans...
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources... -
Multi-omic investigations of mouse liver subjected to simulated spaceflight f...
This study compares standard laboratory protocols for tissue freezing and storage with a simulation of the delayed processing of liver specimens and long-term storage protocols... -
Adaptive changes in the vestibular system of land snail to a 30-day spaceflig...
The vestibular system receives a permanent influence from gravity and reflexively controls equilibrium. If we assume gravity has remained constant during the species evolution...